RN-1 dihydrochloride
CAS No. 1781835-13-9
RN-1 dihydrochloride ( —— )
Catalog No. M27442 CAS No. 1781835-13-9
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 61 | Get Quote |
|
5MG | 102 | Get Quote |
|
10MG | 177 | Get Quote |
|
25MG | 354 | Get Quote |
|
50MG | 556 | Get Quote |
|
100MG | 791 | Get Quote |
|
500MG | 1611 | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameRN-1 dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionRN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
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DescriptionRN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).(In Vitro):RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively.(In Vivo):In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetHistone Demethylase
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1781835-13-9
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Formula Weight452.4
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Molecular FormulaC23H31Cl2N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.Cl.CN1CCN(CC1)C(=O)CNC1CC1c1ccc(OCc2ccccc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ye W, Zhang Q, Hsiao WW, Zhao S, Che CT. New lupane glycosides from Pulsatilla chinensis. Planta Med. 2002;68(2):183-186.
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